slatestarcodex autism

Like many DSM diagnoses it is a junkheap of often unrelated symptoms wrapped up in a single label for essentially politically reasons. The fact that nobody has noticed and studied an effect in a subgroup is evidence that the subgroup does not have a large effect. If autism is a result of piling up too many high-IQ alleles, then youd expect to see far more of it in the children of scientists, lawyers, engineers, doctors, mathematicians, etc., than in the children of janitors, file clerks, policemen, nurses, etc. AISafety.com hosts a Skype reading group Wednesdays at 19:45 UTC, reading new and old articles on different aspects of AI Safety. I have a day job and SSC gets free hosting, so don't feel pressured to contribute. When I was in high school one of my coaches called them, air muscles. Its when a guy can bench 300, squat 500, etc and still get overpowered by a guy who does half that. Other possible explanation(s): Some kind of anxiety about doing things wrong, combined with worrying about whether one is supposed to be able to do a thing yet. Or in the case of plants, their leaf structures are generated by a fractal pattern, and even small changes in the parameters of that fractal cause large changes in the ultimate pattern in a way that is chaotic and difficult to predict. But they can only screen for de novo mutations they know about, and it could be that they just missed some. * Expect to be recognized as superior even without achievements that warrant it. But extra cash helps pay for contest prizes, meetup expenses, and me spending extra time blogging instead of working. I dont have time to go through all the links this morning but wanted to add some more studies. As an example of the latter there was a time when I was in math class when wed started learning about simple equations with variables (4n + 2 = 3n + 5 or whatever) but we hadnt yet learned about adding things to both sides (I think we were just supposed to guess and check). But it adds the concept of a "safe starch" - where the classic paleo diet has a zero tolerance policy toward carbohydrates, the Perfect Health Diet allows certain carbs like rice, potatoes, and lots of weird things like "taro" and "sago". If the curve stayed exactly the same and there was a correlation between IQ > arb. no IQb + low genetic load : high intelligence, sociable, not so technically inclined You tell them that the study that tried to address that question suggests that they are between one point one and one point two times as likely; in other words, at least 83-90% of their chance to have autistic children is baseline. Also, the Gardner paper has analyzed autistic patients fathers by subtype of intelligence, and there is a nonsignificant but pretty suggestive tendency for them to have higher-than-normal verbal intelligence; certainly no signs of high verbal intelligence preventing autism. Additionally, look at the lives of geniuses throughout American history. I dont know. Get the latest business insights from Dun & Bradstreet. For example, why do people with down syndrome or williams syndrome have differently shaped faces? So by comparison, I could imagine that theres a bunch of gene variants that increase limb length, and that if you have a certain number of these you get some nice Usain Bolt proportions that help you win races. The genes that control the development of that definitely dont do so in a linear or easily explainable way. Plenty of people are both smarter and more charismatic than us. 2016, p. 118), and there are many individually varied connections between brain and behavior (Kennedy et al. While their children are clearly at higher risk for autistic traits, I think they want to know whether they have higher risk for the most severe forms of the syndrome, including intellectual disability and poor functioning. Can we quantify the causality going the other way? Check out the similarities. the genetic load would be due to bad luck in parent mixing (recessive-recessive pairs) and parent age. (*), Its not hard to measure my IQ, except that it generally falls at the top of the scale where the tests dont make effective distinctions. Flynn effect vs genetic selection. If we take the Ronemus and Gardner studies seriously, the answer seems to be yes. I dont know what to make of this: Underconnectivity in autistic brains account for sensory integration differences and gifts. But there is a critical point in the system, the feedback point, after which more isnt just too much of a good thing the behavior of the system changes qualitatively and the whole thing breaks down. This should be surprising; why would too many intelligence-promoting variants cause a syndrome marked by low intelligence? Slate Star Codex For, Then Against, High-Saturated-Fat Diets Posted on March 10, 2020 by Scott Alexander I. Why on Earth one would assume that the effect of genes that contribute to IQ should be linearly additive and increasing to ad infinitum. What is going on? There are ways to reduce the loop gain of the system to increase the maximum gain before feedback, but ultimately they involve careful sound engineering theres no general parameter you can turn down to fix the problem, because the primary parameter you _want_ is the same one that causes the breakdown. Take any part away, and you lose some intellectual ability. Moments of it? I never liked that. On the first level its obviously because of the genetic abnormalities they have, but its not like we could look at those gene differences and predict that those features would develop in that way. Within our filter bubble, people have similar levels of status, so they can be smart but not charismatic or charismatic but not smart. Genes which are helpful until you have too many of them, at which point you are screwed. And autistic people have more health issues than non-autistic people do. Arizone State University Autism symptoms reduced nearly 50% two years after fecal transplant IQb + high genetic load: autism with lowish IQ, always diagnosed as autist The reason seems to be that there is great overlap in symptoms, although there is great diversity in symptoms. The lectins in wheat interfere with leptin receptors, making people leptin resistant and therefore obese. This confuses me a little. Its hard to pin down why this is the case, but I think it is related to the things above, but also to the fact that gifted people tend to be bad at copying other people instinctively. What will be interesting to see if we get weeded out before getting close to the top, and if the breakdown will stay the same. Without the load, the child would have had a high IQ, but with weak fundation (genetic load) no. For, Then Against, High-Saturated-Fat Diets I am not, but we both initially bonded over (I dont know a way to put this delicately or more exactly) being objectively very smart people that dont perform intelligence very well, albeit different ways. Anyway, if the data were there, I would suggest an alternate explanation that a significant portion of gender dysphoria is socially mediated, and the autistic are isolated from the social phenomenon. Precision of it? Slate Star Codex was a blog by Scott Alexander about human cognition Press J to jump to the feed. In particular, this aligns well with the observation that de novo variants are more frequently observed in ASD cases with intellectual disability compared to cases without comorbid intellectual disability, that IQ correlates positively with family history of psychiatric disorders92 and that severe intellectual disability (encompassing many syndromes that confer high risk to ASD) show far less heritability than is observed for mild intellectual disability93, intelligence in general94 and ASDs. The Flynn effect seems to be about raising the floor by building proper sewers and water supplies, eradicating parasites, vaccinating everyone against common childhood diseases, making sure nobody starves and also adding nutritional supplements to foods so brain development isnt stunted by deficiency diseases, eliminating heavy metals from the environment of small children, making sure everyone goes to school, etc. Below are two lists taken from an autism checklist and a reactive attachment disorder list. Im not an expert on biology or genetics or neuropsychology by any means, but I feel like youre onto something with the tower-and-foundation model. There are different levels of the concept we call perfect pitch. (Is that still seen as credible? The results from the large trial seem consistent with there being a yet-undifferentiated subtype of autism that responds moderately to significantly. Earned the Untappd at Home (Level 12) badge! But as mentioned before, autistic people themselves on average have lower intelligence. They find that even autistic people without de novo mutations have lower-than-average IQ. We have another child who shows no autistic traits. Most cases of autism involve all three of these factors; that is, your overall autisticness is a combination of your familial genes, mutations, and environmental risk factors. You can squeeze out a little more gain by filtering just the frequencies that feed back, but if you keep going up it wont take long at all before there are too many to filter. Any gene that increases A in a normal human makes that human more intelligent by pushing A closer to 10. AUCHAN RETAIL INTERNATIONAL - Dun & Bradstreet I have 5 children. Ive looked into this topic myself, not professionally or anything-just as an interested lay researcher with a science/statistics background- and had a less well-articulated formulation of the tower vs. foundation model in mind for awhile, too. The latter are the Feynman types: Goofballs with a myriad of weird interests (Feynman was into playing the Bongo drums and the short lifed Soviet Republic Tannu Tuva, among other things). Wheat has been genetically modified recently in ways that make it much worse for you. In sum, the heterogeneity of risk factors, brain impairments, and non-diagnostic symptoms in an ASD-defined sample blocks valid scientific inference. And also reproducing younger (banking frozen eggs and/or sperm early for the IVF). They all share the same hunger for mathematics, and if you get to know those who seem normal on the surface, you find out that they have some interesting hobbies as well. If a high quantity of a good thing comes with a risk of problems that reduce the quantity again, then you could understand the ability to keep the problems at bay as foundation of the tower. High-functioning autism looks more like the same polygenetic soup one finds with other complex personality characteristics like intelligence or Big Five character traits. When people came to our defense, it was generally with an idea I didnt like too much: that maybe there were different types of intelligence and if we sucked at [x] we must surely be good at [y]like life was an RPG character generator or something. Physically, people with autism might have certain brain structures or modes of neural connection that are associated with high intelligence, but without the surrounding neurological infrastructure necessary to support those structures/functions like the poor Great Dane whose heart is too small and bones are too weak for his frame. I wonder what the genetics for this would look like. People at the higher end of the corporate ladder that Ive met were very intelligent and also seemed generally normal, though of course they had much higher-than-normal ambition, stamina, and interest in their business. By the same rationale, you could say that no one is normal, and everyone is simply running a mental emulation. But if you want to redefine incredible to mean the top 0.1 percent of the population, then yes, Bugmasters guess would be roughly accurate: Thered be approximately 1,250 people who were both incredibly smart and incredibly charismatic in the Western world, or maybe 1,500-2,000 if you assume a minor positive correlation between being intelligence and being socially adept. I would hypothesize based on this that autistic people usually have parents who are very good at exactly those areas that they have trouble in. the classic stereotype.). Meanwhile, placing people on the spectrum equalizes access to resources, including insurance coverage. I dont know why, but my prior is that the mothers age matters more. (Or did, 20+ years ago when I last took an IQ test.) (For example, a too-big head would kill mother and baby until modern times; now it just means mom gets a C-section.). The strong differences in estimated SNP heritability between ASD cases with and without intellectual disability, and highest in Aspergers provide genetic evidence of longstanding observations. (3) Genes that promote autism and IQ are being selected for DESPITE other genes that promote IQ being selected AGAINST, so we would expect to see the representation of autism in (the dwindling fraction of) high-IQ families explode in the coming decades. threshold and massive achievement, massive achievement should have exploded in recent decades. Norwegian founders with an international team on a mission to offer the equivalent of a Norwegian social safety net globally available as a membership. That would give me more than enough money to give the middle finger to all the ignorant normies in our politically correct society, with plenty left over to hire some bodyguards and build mechanical defense systems to insulate me from any of the outraged pearl-clutching idiots who decided to use physical violence against me when their threat of social sanctioning wasnt enough.

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