endophytic squamous proliferation
Before 1999;28(6):2747. 2009;67(1):1406. Head and Neck Pathol 15, 572587 (2021). [42], Non-clavicipitaceous endophytes represent a polyphyletic group of organisms. Observer variability in the histologic assessment of oral premalignant lesions. No external funding was obtained for this study, with support from institutional review boards and the sponsoring societies. Squamous cell papilloma (SCP) is defined as a benign proliferation of the surface epithelium of various organs including the skin, lip, tongue, oral cavity, larynx, [59] Three triterpenes were found in the endophyte Xylarialean sp., all three of these compounds displayed mild cytotoxic effects on tumor cells. Why oral histopathology suffers inter-observer variability on grading oral epithelial dysplasia: an attempt to understand the sources of variation. Indian J Dent Res. Atypical Squamous Proliferation: What Lies Beneath Compact hyperkeratosis often fills the spaces between the verrucous projections (Figure 3, A).24,25,37 Fibrovascular cores tend to be thin and inconspicuous relative to the hypertrophic epithelium. There is no evidence of koilocytosis (hematoxylin-eosin, original magnifications 20 [A] and 200 [B]). Epub 2016 Jun 14. NCI CPTC Antibody Characterization Program. Papillomatous and endophytic squamous proliferation is present with keratin plug, parakeratin, and mild pleomorphism of keratinocytes extending to the base of the biopsy (a). Because histopathologic findings can vary in women with multiple SCC lesions, from keratoacanthoma-like to well-differentiated SCC, we hypothesized that TP53 variants might shed light on the appropriate classification. Behura SS, Masthan MK, Narayanasamy AB. Endophytic type squamous cell papilloma, is continuous with the adjacent hyperplastic epidermis and a crater forms by invagination with no pedicle. This endophytic type has neither invasive nor compressive growth into surrounding tissues. Keratoacanthoma and infundibulocystic squamous cell carcinoma. Bulky squamous epithelial proliferation with an exophytic and/or endophytic growth pattern (the former often associated with corrugated/verrucous/papillary architecture). Pentenero M, Meleti M, Vescovi P, Gandolfo S. Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? [15], Studies have shown that endophytic fungi grow in a very intimate interaction with their host plant cells. [51], A 2008 experiment with an isolate of a fungus called NRRL 50072 found that this strain can produce a small amount of fuel-like hydrocarbon compounds which was promoted as "myco-diesel". Braz J Otorhinolaryngol. Akrish S, Eskander-Hashoul L, Rachmiel A, Ben-Izhak O. Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: a literature review and analysis. A, This lesion shows flat acanthosis with full-thickness basaloid atypia. Published by Elsevier Inc. All rights reserved. Epub 2011 Feb 22. [73], There are several endophytes that have been discovered that exhibit insecticidal properties. eCollection 2019 Dec. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. A common diagnostic quandary is regarding anogenital seborrheic keratosis (SK)like lesions without identifiable koilocytes (Figure 1, C). Although endophytic bacteria and fungi are frequently studied, endophytic archaea are increasingly being considered for their role in plant growth promotion as part of the core microbiome of a plant. Similar lesions frequently harbor human papillomavirus and should at least raise suspicion for a seborrheic keratosis-like condyloma acuminatum. 2011 Mar;37(3):395-8. doi: 10.1111/j.1524-4725.2011.01895.x. Med Oral Patol Oral Cir Bucal. Architectural Alterations in Oral Epithelial Dysplasia are - Springer [24], Endophytic species are very diverse; only a small minority of existing endophytes have been characterized. Oral Oncol. Endophytic Fungus - an overview | ScienceDirect Topics IFK clinically and pathologically resembles other malignant Class 1 endophytes are mainly transmitted from host to host by vertical transmission, in which maternal plants pass fungi on to their offspring through seeds. Differentiated intraepithelial neoplasia and lichen sclerosus may be found in the adjacent epithelium.37,51. 2020;42(3):53955. Multiple studies have demonstrated the presence of HPV, predominantly type 6, in up to 70% of anogenital SKs.1014 In contrast, HPV was rarely detected in extragenital SK and other nonHPV-mediated lesions on genital skin (such as fibroepithelial polyp, epidermolytic acanthoma, and chronic dermatitis).12,13 These findings suggest that genital SK is at least similar or related to condyloma acuminatum. JAAD Case Rep. 2019 Nov 20;5(12):1051-1054. doi: 10.1016/j.jdcr.2019.08.008. The objective of this study was to produce an expert consensus guideline for standardized assessment and reporting by pathologists diagnosing PVL related lesions. The second method divides fungal endophytes into four groups based on taxonomy and six other criteria: host range, host tissues colonized, in planta colonization, in planta biodiversity, mode of transmission and fitness benefits. They were thought to be plant parasitic fungi and they were later termed as "microzymas" by the French scientist Bchamp. Copyright 2017 American Academy of Dermatology, Inc. [62], Endophytes have been discovered with various anti-tumor properties. 2020;14(4):91522. Occasionally, keratinizing SCC may occur.37,38, As a surrogate marker for high-risk HPV infection, p16 immunohistochemical stain serves as a helpful tool to distinguish warty, basaloid, and warty-basaloid squamous neoplasms from condyloma acuminatum and HPV-independent (differentiated) squamous neoplasms. Ancillary tools available for identifying and genotyping human papillomavirus can aid in diagnosis when histopathologic findings are inconclusive. Atypical Squamous Proliferation: What Lies Beneath?, Dermatologic Surgery | 10.1111/j.1524-4725.2011.01895.x | DeepDyve DeepDyve Get 20M+ Full-Text Papers For Less Than $1.50/day. Keratoacanthoma, committed stem cells and neoplastic aberrant infundibulogenesis integral to formulating a conceptual model for an infundibulocystic pathway to squamous cell carcinoma. Sinonasal papilloma There was moderate agreement (>0.41 kappa) for 35 of 48 cases. The rest of the keratinocytes appear normal. Proliferative verrucous leukoplakia: diagnosis, management and current advances. National Library of Medicine Extraoral lesions are rare and usually arise on the vulva, penis, scrotum, and extremities.88 Most patients present with a solitary lesion, although coexistence of multiple lesions can occur. Upadhyaya JD, Fitzpatrick SG, Islam MN, Bhattacharyya I, Cohen DM. Aside from koilocytosis, cytologic atypia is absent (Figure 2, B). One example of this plant-endosymbiont interaction occurs between dicotyledonous plants in the Convolvulaceae and clavicipitaceous fungi. Endophytic fungi are ubiquitous to plants and are mainly members of Ascomycota or their mitosporic fungi, and some taxa of Basidiomycota, WebIn this image, you can also see endoplasmic reticulum, Golgi apparatus and cell wall. Surgery. Among these three types of clavicipitaceous endophytes are different interactions with their plant hosts. This fungus yields a metabolite that shows potential as an antidiabetic, also known as an insulin mimetic. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in Am J Dermatopathol. The first method divides endophytes into two categories: systemic (true) and nonsystemic (transient). Unlike lesions infected with high-risk HPV, which are diffusely and strongly positive for p16, condylomas display negative, focal, or patchy staining (Figure 1, D).17,18 When necessary, testing for low-risk HPV (types 6 and 11) by PCR-DNA sequencing, in situ hybridization, or immunohistochemistry may also aid in diagnosis.19, Giant condyloma acuminatum is a large, fungating, and locally destructive form of condyloma acuminatum. From the Department of Pathology, University of Michigan Health System, Ann Arbor. Solitary epidermolytic acanthoma: a clinical and histopathological study, Inherited nonsyndromic ichthyoses: an update on pathophysiology, diagnosis and treatment, Histopathologic varieties of epidermal nevus: a study of 160 cases, Linear epidermolytic verrucous epidermal nevus of the male genitalia, Epidermolytic hyperkeratosis associated with melanocytic nevi: a report of 53 cases, Incidental cutaneous reaction patterns: epidermolytic hyperkeratosis, acantholytic dyskeratosis, and hailey-hailey-like acantholysis: a potential marker of premalignant skin change, Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis, Epidermolytic acanthoma of the genitalia does not show mutations in KRT1 or KRT10, Epidermolytic acanthomas: clinical characteristics and immunohistochemical features, Vegas (verruciform genital-associated) xanthoma: a comprehensive literature review, Vulvar verruciform xanthoma: ten cases associated with lichen sclerosus, lichen planus, or other conditions, Verruciform xanthoma of the penis: a rare benign lesion that simulates carcinoma, Verruciform xanthoma in an immunocompromised patient: a case report and immunohistochemical study, Characterization of verruciform xanthoma by in situ hybridization and immunohistochemistry, Cutaneous verruciform xanthoma: a report of five cases investigating the etiology and nature of xanthomatous cells, Verruciform xanthoma in the setting of cutaneous trauma and chronic inflammation: report of a patient and a brief review of the literature, Verruciform xanthoma: a clinical, light microscopic, and electron microscopic study of two cases, Kristine M. Cornejo, MD, Lloyd Hutchinson, PhD, Patrick O'Donnell, DO, Xiuling Meng, MD, Keith Tomaszewicz, BS, MT(ASCP), Sara C. Shalin, MD, PhD, David S. Cassarino, MD, May P. Chan, MD, Timothy R. Quinn, MD, Paul B. Googe, MD, Rosalynn M. Nazarian, MD, Ridhi Sood, MBBS, MD, Debajyoti Chatterjee, MBBS, MD, DM, Pinaki Dutta, MBBS, MD, DM, Bishan Dass Radotra, MBBS, MD, MAMS, PhD, Gurpal Bisra, MMOR, MSc, BASc, Brigette Rabel, MLT, Nick van der Westhuizen, MB, FRCPC, Jing Wang, MD, PhD, Yan Peng, MD, PhD, Hongxia Sun, MD, PhD, Phyu P. Aung, MD, PhD, Erika Resetkova, MD, PhD, Clinton Yam, MD, MS, Aysegul A. Sahin, MD, Lei Huo, MD, PhD, Qingqing Ding, MD, PhD, Abha Goyal, MD, Christine N. Booth, MD, Rhona J. Souers, MS, Sana O. Tabbara, MD, Janie Roberson, SCT(ASCP), Michael R. Henry, MD, Kaitlin E. Sundling, MD, PhD, Kelly Goodrich, CT(ASCP), Lananh Nguyen, MD, Mohammed Amer Swid, MD, Liping Li, MD, Erin M. Drahnak, BS, Hayden Idom, BS, William Quinones, MD, Jianhong Li, MD, Myra L. 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