milk thistle depression

Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure youre on a federal Milk thistle is a plant named for the white veins on its large prickly leaves. Why does zinc cause anxiety and depression for some people? Clipboard, Search History, and several other advanced features are temporarily unavailable. Milk thistle may also be used for purposes not listed in this product guide. https://www.wolterskluwercdi.com/facts-comparisons-online/. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Cathy Wong is a nutritionist and wellness expert. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Med Assoc Thai. Unable to load your collection due to an error, Unable to load your delegates due to an error. Research Breakdown on Milk Thistle - Examine Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Also known as Silybum marianum, milk thistle is a perennial herb native to many continents and countries across the globe, including Southern Europe, Southern Russia, Asia Minor, Northern Africa, and the Americas. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. And, most recently, milk thistle is gaining traction as a natural remedy to help manage the symptoms of OCD. Milk thistle can trigger allergic reactions. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . Effects of Silybum marianum (L.) Gaertn. Phytomedicine. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. Milk thistle seems to have few side effects, even when taken for several years. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. This site needs JavaScript to work properly. Advanced Milk Thistle, 120 softgels - Life Extension Milk Thistle Health Benefits: Antioxidant and Anti-inflammatory People with diabetes often have high cholesterol. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Song X, Zhou B, Zhang P, Lei D, Wang Y, Yao G, Hayashi T, Xia M, Tashiro S, Onodera S, Ikejima T. Neurochem Res. FOIA 10 Supplements You Should Be Taking After Menopause If you take any medicines regularly, talk to your doctor before you start using milk thistle. It is not known whether milk thistle will harm an unborn baby. Some medications have been known to interact with milk thistle negatively. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. Milk Thistle. Some of the studies have been of poor quality, too. . These products are not intended to diagnose, treat, cure, or prevent any disease. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. Anticancer Drugs. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Epub 2013 Oct 14. Milk Thistle: Benefits, Uses, Side Effects, and More Nat Neurosci. Antidepressant and Anti-anxiety Effects of Milk Thistle Natural Medicines website. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. Tadaah, perhaps a partly explanation for your experience? 2020;10(3):236-244. doi:10.1016/j.jtcme.2020.02.003. Milk Thistle Treatment for Children and Adults with - PubMed A survey conducted in the U.S. reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. In: Drugs and Lactation Database (LactMed). 2007 Sep;10(9):1089-93. doi: 10.1038/nn1971. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). Its been suggested that oxidative stress in the body may play a role in the development of acne (41). Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Studies on cancer cell lines (done in the laboratory) have found that elements in milk thistle: Researchers also are looking at how milk thistle might complement traditional care and treatment in people diagnosed with gastrointestinal cancers. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. Milk thistle supplements, for . Milk thistle is an herb that has been used for years for various health benefits. Learn more about natural remedies for type 2 diabetes. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. It is primarily considered a cleansing agent and used to block or flush toxins from the body. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. Bookshelf Accessed Oct. 30, 2020. Have direct benefits against prostate, breast, and certain cervical cancer cells. This content does not have an English version. It may have protective effects on the liver, preventing damage. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. When considering the use of herbal supplements, seek the advice of your doctor. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Occasionally, people report various digestive side effects. Interactions. Beware that milk thistle can worsen depression, it doesn't act the same on everybody. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. eCollection 2022. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Rev Diabet Stud. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial, By Soraiya Ebrahimpour Koujan, Bahram Pourghassem, Gargari Majid, Published February 15, 2015, Retrieved May 5, 2019, 8. https://www.ncbi.nlm.nih.gov/pubmed/28025940, Current Drug Targets, A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin, By Devi KP, Malar , Braidy , Nabavi , Nabavi, Published 2017, Retrieved May 5, 2019, 9. https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1964, Toxnet, Valerian Root, Reviewed by SRP on 9/9/2014, Retrieved May 5, 2019, 10. https://nccih.nih.gov/research/results/spotlight/040310.htm, National Center for Complementary and Integrative Health, Study Shows Chamomile Capsules Ease Anxiety Symptoms, Last Updated October 21, 2015, Retrieved May 5, 2019, 11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612440/, Evidence Based Complementary Medicine, Lavender and The Nervous System, Published March 14, 2013, By Peir Hossein Koulivand, Maryam Khaleghi Ghadiri, and Ali Gorji, Retrieved May 5, 2019, 12. https://www.webmd.com/vitamins/ai/ingredientmono-437/lemon-balm, WebMD.com, Lemon Balm, Retrieved May 5, 2019, Requirements for using and reposting articles. privacy practices. 2012;308(3):274-282. doi:10.1001/jama.2012.8265, Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful . Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). a history of endometriosis or uterine fibroids. Hepatology. Milk Thistle Benefits, Side Effects and Dosage Recommendation - Dr. Axe Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). J Diabetes Res. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Historically, people have used milk thistle for liver disorders and gallbladder problems. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Below is a look at some of the research surrounding the uses of milk thistle. The best doses of milk thistle have not been established for any condition it may be used to treat. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010, Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

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