infed stability after reconstitution

Do not administer Infed to patients with evidence of iron overload. . To calculate a patient's weight in kg when lbs are known: Otherwise, the total dose may be calculated using the formula below: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x W + (0.26 x W), Desired Hb = the target hemoglobin in g/dL [Normal hemoglobin for children with body weight of 15 kg (33 lbs) or less is 12 g/dL.]. 0000010118 00000 n Niemiec PW Jr, Vanderveen TW, Hohenwarter MW, Gadsden RH Sr. Bullock L, Fitzgerald JF, Glick MR, Parks RB, Schnabel JG, Hancock BG. In iron-deficient patients with coexistent end-stage renal disease and other clinical problems, the serum elimination half-life of iron averaged 58.9 hours (range: 9.487.4 hours) following IV administration of iron dextran. The animals used in these tests were not iron deficient. Parenteral iron administration may be associated with hypersensitivity reactions [see Warnings and Precautions (5.1)], which may have serious consequences, such as fetal bradycardia (see Clinical Considerations). For information on systemic interactions resulting from concomitant use, see Interactions. Each days dose should ordinarily not exceed 0.5 mL (25 mg of iron) for infants under 5 kg (11 lbs); 1.0 mL (50 mg of iron) for children under 10 kg (22 lbs); and 2.0 mL (100 mg of iron) for other patients. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. @['/=yWb7m$Hl%B0p`5s['9t YR=7lVnsuQ~ Use the following formula to calculate required total iron dextran dosage in mL: 0.02 blood loss (in mL) hematocrit (expressed as a decimal fraction) = total dosage of iron dextran injection (mL). 5.1 Hypersensitivity Reactions Thank you for submitting a comment on this article. If no adverse reactions are observed, INFeD can be given according to the following schedule until the calculated total amount required has been reached. Discontinue oral iron therapy prior to initiation of iron dextran therapy. Careers. The study suggests that addition of recommended daily doses of iron dextran to parenteral nutrient solutions creates no stability problems; however, further study of the effects of temperature, pH, light, and storage time are recommended. The site is secure. Please check for further notifications by email. 0000001168 00000 n Possible increased incidence of adverse effects, especially delayed reactions, associated with large IV doses of iron dextran, such as those used in total-dose infusions. sharing sensitive information, make sure youre on a federal 3. 0000002909 00000 n HdTn0D [See USP Controlled Room Temperature]. Iron Dextran (INFeD or DexFerrum ) INFeD and DexFerrum are iron dextran pro-ducts marketed in the United States. The adverse reactions are frequently delayed (1 to 2 days) reactions typified by one or more of the following symptoms: arthralgia, backache, chills, dizziness, moderate to high fever, headache, malaise, myalgia, nausea, and vomiting. Calculate the Infed dose based upon Table 1 and formulas below. 2 0 obj Copyright 2021 GlobalRPH - Web Development by, The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to iron dextran. Copyright 2023, Selected Revisions November 4, 2013. .65 mL/kg of body weight, b. m$K~*&S)j5-Df"F d (8-s)h#=xF9+47{%CDQ$EMDH7x$k"$>~ynvloopxfG? Children 5 - 15 kg (11 - 33 lbs): See Dosage Table. Fetal/Neonatal Adverse Reactions During all Infed administrations, observe for signs or symptoms of anaphylactic-type reactions. . HR0~ The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). F'T9CQU!haSuYn5yd)}^O:Cu) ^>?9#f+R' Drug interactions involving Infed have not been studied. endstream endobj 52 0 obj<> endobj 53 0 obj<> endobj 54 0 obj<>stream May also be given IM or slow IVP (1 ml/min x 2 min = 100 mg). It should be understood that these half-life values do not represent clearance of iron from the body. Hbd`ab`ddpwwvL)IMN5405NKIa!#6= v`b`fd4/9(3=DA!YAR1%? Corrects the erythropoietic abnormalities that are due to a deficiency of iron. Accessibility Excretion 0000004693 00000 n The etiology of these reactions is not known. To avoid injection or leakage into the subcutaneous tissue, a Z-track technique (displacement of the skin laterally prior to injection) is recommended. The circulating iron released from iron dextran, which is subject to physiological control, replenishes hemoglobin and depleted iron stores. 2.4 Administration Ferentino, Italy 03013, Distributed By: %%EOF After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. 0000003746 00000 n Br Med J (Clin Res Ed). Such reactions may be immediate or delayed. In vitro studies have shown that removal of iron dextran by dialysis is negligible. Stability of ranitidine hydrochloride and amino acids in parenteral nutrient solutions. ~q`C34&rAd oG Brand and Other Names: INFeD, Dexferrum Classes: Iron Products Dosing & Uses AdultPediatric Dosage Forms & Strengths injectable solution 50mg (Fe)/mL Iron-deficiency Anemia 25-100 mg IV or deep. A current package insert for the iron dextran product being used should always be reviewed, since these package inserts are periodically updated, and the product is currently made by more than one manufacturer. 0000024030 00000 n Patients with a history of significant allergies and/or asthma may have an increased risk of hypersensitivity reactions [see Dosage and Administration (5.1)]. 4. 0000002072 00000 n 0 Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. Elimination of iron from serum, including elimination half-life, does not correspond to clearance of the mineral from the body. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses. General . (See Boxed Warning.). Serum ferritin peaks approximately 7 to 9 days after an intravenous dose of Infed and returns to baseline after about 3 weeks. Epinephrine should be immediately available. During all Infed administrations, observe patients for signs or symptoms of anaphylactic-type reactions. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant persons with intravenous iron administration (such as Infed) which may have serious consequences on the fetus such as fetal bradycardia, especially during the second and third trimester. 1989;23(4):197-207. doi: 10.1007/BF00451642. Copyright 1993-2021 0000015331 00000 n INFeD preparation: Administer by deep IM injection using a 2- or 3-inch, 19- or 20-gauge needle into the upper outer quadrant of the buttock only. Seven formulations for dilute (50 mg/dl) iron dextran solutions and four parenteral nutrient solutions containing 100 mg/liter of iron dextran were prepared. Therefore, administration of subsequent test doses during therapy should be considered.

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